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KMID : 1123920160300060432
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Korean Journal of Oriental Physiology and Pathology
2016 Volume.30 No. 6 p.432 ~ p.438
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Melanogenic Effect of Eclipta Prostrata (L.) L.
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Cha Su-Bin
Park In-Hae
Hong Seok-Hoon
Mun Yeun-Ja
Woo Won-Hong
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Abstract
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This study was peformed to investigate the mechanism of ethanol extract of Eclipta Prostrata (L.) L. (EEP) induced melanogenesis. EEP enhanced tyrosinase activity and melanin contents of B16F10 cells. Moreover, EEP increased the protein expression of tyrosinase and tyrosinase-related protein 1 (TRP-1). But EEP did not increase the protein expression of tyrosinase-related protein 2 (TRP-2). These results suggest that melanogenesis-promoting effect of EEP was involved in regulation of tyrosinaase and TRP-1 protein, and EEP may be a potent pigmentation darkening agent in hypopigmentation condition.
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KEYWORD
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Eclipta prostrata (L.) L. , Melanogenesis , Tyrosinase , TRP-1 , TRP-2
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